SAN DIEGO — After decades of failing to develop an effective vaccine against HIV, the federal government has committed $129 million to a new effort led by Scripps Research.

The National Institutes of Health award was announced Wednesday. It will fund development and testing of a multistage preventive vaccine. The work will be performed by the Consortium for HIV/AIDS Vaccine Development, or CHAVD, an international collaboration.

Scripps Research scientists in La Jolla will get about half the money over the grant’s seven-year life, said Dennis Burton, co-chair of the Department of Immunology and Microbiology at Scripps Research, and CHAVD’s director. The rest goes to 13 other CHAVD groups, including projects at four foreign locations.

The grant from NIH’s National Institute of Allergy and Infectious Diseases puts into action knowledge gained from research under a previous seven-year grant, Burton said. A series of shots is envisioned to “train” the immune system how to make powerful antibodies that neutralize a broad range of HIV strains.

“We’ve shown it worked in animal models. So what we have to do now is to bring that to human reality,” Burton said.

This “sequential” vaccination is necessary because the immune system must be coaxed along before it can effectively fight HIV, said Dr. Anthony Fauci, NIAID’s director.

“You can’t just do what you do with measles vaccine, where you give a shot or two and then the body immediately makes the right kind of antibody,” Fauci said.

Broadly neutralizing antibodies were discovered from the blood of those with HIV. These antibodies typically take years for the immune system to learn how to make. By that time, HIV is too well established for the body to eradicate.

The multistage vaccine is intended to compress this immune education process into several months, Burton said. It’s not yet known how long the process will take, or how many stages.

“We’ll have three, four or maybe five immunizations,” Burton said. “But what will be in the syringe will be different each time, as we as we take the antibody response to the place we wanted to be, which is these broadly neutralizing antibodies.”

The complete sequence will probably take around nine months to deliver, with doses spaced a few months apart, Burton said. The precise timing will be worked out as each stage of the vaccine is given and the immune response assessed.

Immunization to kick off the response began last September, Burton said. Results on this first stage should be available later this year.

The previous grant resulted in a cascade of discoveries about how the human immune system can defend itself against HIV.

Some of this work focused on understanding how the broadly neutralizing antibodies stop HIV. Other work concerned what needed to be done to generate these antibodies.

You must be logged in to react.
Click any reaction to login.
0
0
0
0
0

Load comments